{"doc_desc":{"title":"20,000 Volunteers for Medical Research","idno":"FRESH-PEF3476-en","producers":[{"name":"Marcel GOLDBERG","affiliation":"UNIVERSITE PARIS-SACLAY"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF3476-en","IDno":{"metadata_no":[{"agency":"PEF","code":"3476"},{"agency":"FReSH","code":"FRESH-PEF3476"}]},"title":"20,000 Volunteers for Medical Research","alternate_title":"GAZEL"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Marie;ZINS","PILabo":"Paris Saclay University, University of Paris, Versailles University, INSERM \/ UMS 011 : Cohortes \u00e9pid\u00e9miologiques en population","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ORCID","uri":"0000-0002-4540-4282","role":"pi id"},{"title":"IdRef","uri":"074613324","role":"pi id"},{"title":"SIREN","uri":"180036048","role":"organisation id"},{"title":"RNSR","uri":"201322808P","role":"labo id"}],"email":"marie.zins@inserm.fr","isContact":"Yes"},{"type":"investigator","name":"Marcel;GOLDBERG","PILabo":"","affiliationName":"UNIVERSITE PARIS-SACLAY","extlink":[{"title":"ORCID","uri":"0000-0002-6161-5880","role":"pi id"},{"title":"IdRef","uri":"028740637","role":"pi id"},{"title":"SIREN","uri":"130026024","role":"organisation id"},{"title":"RNSR","uri":"201420731C","role":"labo id"}],"email":"marcel.goldberg@inserm.fr","isContact":"Yes"}],"oth_id":[{"name":"Consortiums and collaborations :- Sickness Absence Research Collaboration (SARC) : http:\/\/ucl-sarc.org\/index.html - IDEAR (Integrated Datasets across Europe for Ageing Research)- BBMRI-LPC- P3G","type":"collaboration"}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"sponsor id"},{"title":"SIREN","uri":"180036048","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"GIS-INSTITUT POUR LA RECHERCHE EN SANTE PUBLIQUE (IRESP)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/05fw72335"}]},{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261"},{"title":"SIREN","uri":"180036048"}]},{"name":"CCAS","extlink":[]},{"name":"CNAM","extlink":[]},{"name":"CMCAS","extlink":[]}]},"distribution_statement":{"contact":[{"name":"Marie;ZINS","email":"marie.zins@inserm.fr","type":"contact","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id","title":"ROR"},{"uri":"180036048","role":"organisation id","title":"SIREN"}]},{"name":"Marcel;GOLDBERG","email":"marcel.goldberg@inserm.fr","type":"contact","affiliationName":"UNIVERSITE PARIS-SACLAY","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/03xjwb503","role":"organisation id","title":"ROR"},{"uri":"130026024","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"adults"},{"keyword":"occupational health"},{"keyword":"social determinants"},{"keyword":"aging"},{"keyword":"General-purpose cohort"}],"topics":[{"topic":"COVID-19","vocab":"cim-11","extLink":[{"uri":"http:\/\/id.who.int\/icd\/entity\/1730556128","title":"CIM-11"}]},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Environmental determinants: Other","vocab":"health determinant"},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Behavioral determinants: Eating habits","vocab":"health determinant"},{"topic":"Environmental determinants","vocab":"health determinant"},{"topic":"Healthcare system determinants: Use of care","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants: Employment","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"},{"topic":"Healthcare system determinants","vocab":"health determinant"}],"purpose":"GAZEL was set up in 1989 among workers of \u00c9lectricit\u00e9 de France-Gaz de France (EDF-GDF). It was designed as an \u201copen epidemiologic laboratory\u201d characterized by a broad coverage of health problems and determinants and accessible to the community of researchers. At study inception in 1989, the GAZEL Cohort Study included 20,625 volunteers (15,011 men and 5,614 women) then aged from 35 to 50 years. The data routinely collected cover diverse dimensions and come from different sources: annual self-administered questionnaire (morbidity, lifestyles, life events, etc.); personnel department of EDF-GDF for social, demographic, and occupational characteristics; EDF-GDF special social insurance fund (for sickness absences and cancer and ischemic heart disease registries), occupational medicine (occupational exposure and working conditions), Social Action Fund (healthcare utilization), Health Screening Centres for standardized health examination and the National Death Register (causes of death); a biobank including more than 8,000 blood samples was also set up. Today, more than 40 ancillary projects on diversified themes have been set up in the GAZEL Cohort Study by some 30 French and foreign teams from Denmark, Germany, Belgium, Canada, Great Britain, Sweden, Finland, and USA. Health problems as diverse as migraine, postmenopausal osteoporosis, ischemic heart disease, depression, musculoskeletal diseases, or traffic accidents have been the object of research projects in this cohort. They take into account risk factors that are behavioural, social, psychological, occupational, and medical. A substantial proportion of the research work has focused on the problem of social inequalities in health and their occupational, personal, and social determinants using a life course perspective.","abstract":"","coll_dates":[{"start":"1989-01-01","end":"2024-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Middle Aged (45 to 64 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Aged (65 to 79 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Aged, 80 and over (80 years and more)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"General population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"EDF-GDF workers aged 35-50 at inception.\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Participant-reported health data','Biological data','Socio-demographic data','Paraclinical data (non-biological) : Anthropometry','Paraclinical data (non-biological) : Other']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Health event\/morbidity\r\nHealth event\/mortality\r\nHealth care consumption and services\r\nQuality of life\/health perception"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Other\"}']","sample_frame":{"frame_unit":{"unit_type":"['Population database for statistical purposes Administrative database (employees, pupils, students, etc.)']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"SelfAdministeredQuestionnaire\",\"vocab\":\"CESSDA\"},\"value\":\"Self-administered questionnaire\"}"],"research_instrument":"Free access","sources":[{"sourceCitation":{"titlStmt":{"titl":""},"holdings":"","notes":{"subject":"source purpose","value":""}},"srcOrig":["Medico-administrative database"]}],"target_sample_size":">= 20000 individuals","response_rate":"20 625"},"method_notes":"Observational Study","study_class":"Unknown","notes":[{"subject":"research type","values":["Observational Study"]},{"subject":"observational study method","values":["Cohort study"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Restricted access\",\"extLink\":[{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"}]}"},"dataset_use":{"restrictions":"","conditions":"","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":""}],"deposit_req":"","cit_req":""},"notes":"Permanent call for research projects Data catalogue available on dedicated website"}},"additional":{"IsImport":true,"versionLang":"en","originLang":"en","autoTranslation":false,"status":"imported","creationDate":"25-04-2012","lastUpdatedAuto":null,"lastUpdatedManual":"01-10-2021","isContributorPI":"No","contributorName":"Marcel GOLDBERG","contributorAffiliation":"UNIVERSITE PARIS-SACLAY","addTeamMember":"","obtainedAuthorization":{"otherAuthorizingAgency":[]},"relatedDocument":[],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)","Public (France)","Other","Public (France)","Other"],"otherFundingAgentType":["","","","",""]},"sponsor":{"sponsorType":["Public 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Follow-up also through national health and socioeconomic administrative databases.","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":"Yes"},"geographicalCoverage":{"geoDetail":"All France"},"dataTypes":{"clinicalDataDetails":"","biologicalDataDetails":"Blood count, glucose, total cholesterol, HDL cholesterol, ALT, creatinine, triglycerides, micro albumin, Gamma GT","isDataInBiobank":"Yes","biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[""]},"isHealthTheme":"No","fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}