{"doc_desc":{"title":"Base Anatomo-Clinique de l'ad\u00e9nocarcinome Pancr\u00e9atique","idno":"FRESH-PEF38993-fr","producers":[{"name":"Barbara BOURNET","affiliation":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF38993-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"38993"},{"agency":"FReSH","code":"FRESH-PEF38993"}]},"title":"Base Anatomo-Clinique de l'ad\u00e9nocarcinome Pancr\u00e9atique","alternate_title":"BACAP"},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"type":"investigator","name":"Barbara;BOURNET","PILabo":"CHU Toulouse \/ Gastro-ent\u00e9rologie et nutrition","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","extlink":[{"title":"ORCID","uri":"0000-0002-3679-9454","role":"pi id"},{"title":"IdRef","uri":"083302158","role":"pi id"},{"title":"SIREN","uri":"263100125","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"bournet.b@chu-toulouse.fr","isContact":"Oui"},{"type":"investigator","name":"Cindy;CANIVET","PILabo":"CHU Toulouse","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"140253157","role":"pi id"},{"title":"SIREN","uri":"263100125","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"canivet.c@chu-toulouse.fr","isContact":"Oui"}],"oth_id":[{"name":"BACAP est constitu\u00e9e d'un r\u00e9seau de cliniciens (m\u00e9decins et chirurgiens), anatomopathologistes, \u00e9pid\u00e9miologistes, de chercheurs","type":"collaboration"}],"production_statement":{"prod_place":"Portail Epid\u00e9miologie France (PEF)","producers":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/017h5q109","role":"sponsor id"},{"title":"SIREN","uri":"263100125","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"INSTITUT NATIONAL DU CANCER (INCA)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/03m8vkq32"},{"title":"SIREN","uri":"187512777"}]}]},"distribution_statement":{"contact":[{"name":"Barbara;BOURNET","email":"bournet.b@chu-toulouse.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/017h5q109","role":"organisation id","title":"ROR"},{"uri":"263100125","role":"organisation id","title":"SIREN"}]},{"name":"Cindy;CANIVET","email":"canivet.c@chu-toulouse.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/017h5q109","role":"organisation id","title":"ROR"},{"uri":"263100125","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"Donn\u00e9es cliniques"},{"keyword":"\u00e9chantillons biologiques"},{"keyword":"carcinogen\u00e8se pancr\u00e9atique"},{"keyword":"diagnostic"},{"keyword":"d\u00e9pistage"},{"keyword":"cible th\u00e9rapeutique"},{"keyword":"cachexie"},{"keyword":"biomarqueur"},{"keyword":"signature prot\u00e9omique"},{"keyword":"microARN"},{"keyword":"ADN g\u00e9nomique"},{"keyword":"micro particules"}],"topics":[{"topic":"Oncologie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/5784b7f1-c7ce-49d9-9f38-aebcda0ff41d"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D008495"}]},{"topic":"Gastroent\u00e9rologie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/a3898340-a42d-4f5e-a822-1de204a9a867"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D005762"}]},{"topic":"Tumeurs malignes, d\u00e9clar\u00e9es ou suppos\u00e9es primitives, de localisations pr\u00e9cis\u00e9es, \u00e0 l'exception des tissus lympho\u00efde, h\u00e9matopo\u00ef\u00e9tique, du syst\u00e8me nerveux central ou de tissus apparent\u00e9s","vocab":"cim-11","extLink":[{"uri":"http:\/\/id.who.int\/icd\/entity\/1643222460","title":"CIM-11"}]},{"topic":"D\u00e9terminants biologiques : Pr\u00e9dispositions g\u00e9n\u00e9tiques","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Alimentation","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9 : Consommation des soins","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Emploi","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques","vocab":"health determinant"}],"purpose":"L\u2019objectif de ce projet est de regrouper des donn\u00e9es cliniques et des \u00e9chantillons biologiques issus de patients porteurs d\u2019un ad\u00e9nocarcinome du pancr\u00e9as afin de les mettre \u00e0 la disposition de la communaut\u00e9 scientifique. Le projet BACAP a pour objectif de soutenir les projets de recherche suivant : - la compr\u00e9hension du d\u00e9veloppement de la carcinog\u00e9n\u00e8se pancr\u00e9atique, - le diagnostic pr\u00e9coce et le d\u00e9pistage du cancer pancr\u00e9atique par l\u2019identification de biomarqueurs des l\u00e9sions pr\u00e9canc\u00e9reuses (signature prot\u00e9omique, microARN, ADN g\u00e9nomique, micro particules) et des risques de thromboses associ\u00e9s, - le d\u00e9veloppement de nouveaux outils in vitro pour le diagnostic du cancer du pancr\u00e9as, - l\u2019\u00e9valuation clinique et biologique du d\u00e9veloppement de la cachexie chez les patients porteurs d\u2019un cancer du pancr\u00e9as, - la d\u00e9termination de facteurs responsables de la diss\u00e9mination des cellules canc\u00e9reuses notamment des marqueurs de l\u2019inflammation, - l\u2019identification des biomarqueurs indicateurs de sensibilit\u00e9 ou de r\u00e9sistance \u00e0 la chimioth\u00e9rapie dans le cancer du pancr\u00e9as, - le d\u00e9veloppement de nouvelles cibles th\u00e9rapeutiques","abstract":"","coll_dates":[{"start":"2014-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Masculin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Adulte (19 \u00e0 24 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adulte (25 \u00e0 44 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Adulte (45 \u00e0 64 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Grand \u00e2ge (80 ans et plus)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Patients porteurs d\u2019un ad\u00e9nocarcinome du pancr\u00e9as prouv\u00e9 cytologiquement et\\\/ou histologiquement\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es cliniques','Donn\u00e9es rapport\u00e9es par le participant de l'\u00e9tude','Donn\u00e9es paracliniques','Donn\u00e9es biologiques','Donn\u00e9es paracliniques (hors biologiques) : Imagerie','Donn\u00e9es paracliniques (hors biologiques) : Autre']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":"['Logiciel Clinsight, la base de donn\u00e9es est g\u00e9r\u00e9e par le centre de traitement de donn\u00e9es de l\\'ICM']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de sant\u00e9\/mortalit\u00e9"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Via des structures (services ou \u00e9tablissements de sant\u00e9, \u00e9coles, entreprises\u2026)']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}"],"research_instrument":"Acc\u00e8s restreint sur projet sp\u00e9cifique","sources":[],"target_sample_size":"[1000-10000[ individus","response_rate":"1250"},"method_notes":"Etude observationnelle","study_class":"Inconnu","notes":[{"subject":"research type","values":["Etude observationnelle"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Acc\u00e8s r\u00e9serv\u00e9\",\"extLink\":[{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"}]}"},"dataset_use":{"restrictions":"","conditions":"Les donn\u00e9es et les \u00e9chantillons biologiques sont accessibles sur demande. Le formulaire de demande est accessible sur le site internet de la base. Chaque demande sera \u00e9tudi\u00e9e par le comit\u00e9 scientifique de la base.","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":""}],"deposit_req":"","cit_req":""},"notes":""}},"additional":{"IsImport":true,"versionLang":"fr","originLang":"fr","autoTranslation":false,"status":"imported","creationDate":"02-04-2015","lastUpdatedAuto":null,"lastUpdatedManual":"07-08-2019","isContributorPI":"Non","contributorName":"Barbara BOURNET","contributorAffiliation":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","addTeamMember":"","obtainedAuthorization":{"otherAuthorizingAgency":[""]},"relatedDocument":[],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)"],"otherFundingAgentType":[""]},"sponsor":{"sponsorType":["Public (France)"],"otherSponsorType":[""]},"governance":{"committee":"Oui"},"collaborations":{"networkConsortium":"Oui"},"theme":{"complementaryInformation":"","RareDiseases":""},"activeFollowUp":{"isActiveFollowUp":"Oui","followUpModeOther":""},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":"","allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[],"inclusionGroups":[],"collectionProcess":{"collectionModeDetails":"Lors des visites du patient au centre hospitalier correspondant. Recueil par des cliniciens (gastro-ent\u00e9rologues, oncologues, chirurgiens)","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":"Non"},"geographicalCoverage":{"geoDetail":"15 centres : Toulouse (CHU de Toulouse), Montpellier (Institut r\u00e9gional du Cancer de Montpellier et CHU de Montpellier), Marseille (Assistance Publique des H\u00f4pitaux de Marseille - h\u00f4pital Nord et hopital La Timone), Nice (CHU de Nice - h\u00f4pital l\u2019Archet), Lyon (h\u00f4pital priv\u00e9 Jean Mermoz et Centre L\u00e9on B\u00e9rard), Villejuif (Institut Gustave Roussy), Paris (Assistance Publique des H\u00f4pitaux de Paris - h\u00f4pital Saint-Louis), Paris (Clinique du Trocadero), Lille (CHRU de Lille), Bordeaux (CHU de Bordeaux), Pau (CH de Pau)"},"dataTypes":{"clinicalDataDetails":"Imageries, bilan biologiques, examen clinique, traitements et effets secondaires, \u00e9volution du poids, la taille, l'indice de performance OMS, comorbidit\u00e9s m\u00e9dicales, ant\u00e9c\u00e9dents d'autres cancers, la date des premiers sympt\u00f4mes \/ description, diagnostic, tumeur","biologicalDataDetails":"NFS, bilan h\u00e9patique, glyc\u00e9mie, marqueurs tumoraux","isDataInBiobank":"Oui","biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[]},"isHealthTheme":"Oui","fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}