{"doc_desc":{"title":"Prediction of Damage to Organs: Prospective Cohort Study in The General Population on Brain and Cardiovascular Ageing","idno":"FRESH-PEF5047-en","producers":[{"name":"Vanina BONGARD","affiliation":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF5047-en","IDno":{"metadata_no":[{"agency":"PEF","code":"5047"},{"agency":"FReSH","code":"FRESH-PEF5047"}]},"title":"Prediction of Damage to Organs: Prospective Cohort Study in The General Population on Brain and Cardiovascular Ageing","alternate_title":"Mona Lisa - PREDOR"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Emilie;BERARD","PILabo":"CHU Toulouse \/ UMR1295 CERPOP, Equipe Vieillissement - Axe ARTERRE - Atherosclerosis Risk and Treatment Evaluation towards Risk Reduction Epidemiology","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","extlink":[{"title":"ORCID","uri":"0000-0001-5931-2971","role":"pi id"},{"title":"IdRef","uri":"238725936","role":"pi id"},{"title":"SIREN","uri":"263100125","role":"organisation id"},{"title":"RNSR","uri":"202124019W","role":"labo id"}],"email":"emilie.berard@univ-tlse3.fr","isContact":"Yes"},{"type":"investigator","name":"Vanina;BONGARD","PILabo":"CHU Toulouse \/ UMR1295 CERPOP, Equipe Vieillissement - Axe ARTERRE - Atherosclerosis Risk and Treatment Evaluation towards Risk Reduction Epidemiology","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","extlink":[{"title":"ORCID","uri":"0000-0001-5789-0815","role":"pi id"},{"title":"IdRef","uri":"058215573","role":"pi id"},{"title":"SIREN","uri":"263100125","role":"organisation id"},{"title":"RNSR","uri":"202124019W","role":"labo id"}],"email":"Vanina.bongard@univ-tlse3.fr","isContact":"Yes"}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/017h5q109","role":"sponsor id"},{"title":"SIREN","uri":"263100125","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/017h5q109"},{"title":"SIREN","uri":"263100125"}]},{"name":"","extlink":[]},{"name":"","extlink":[]},{"name":"","extlink":[]}]},"distribution_statement":{"contact":[{"name":"Emilie;BERARD","email":"emilie.berard@univ-tlse3.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/017h5q109","role":"organisation id","title":"ROR"},{"uri":"263100125","role":"organisation id","title":"SIREN"}]},{"name":"Vanina;BONGARD","email":"Vanina.bongard@univ-tlse3.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (CHUT)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/017h5q109","role":"organisation id","title":"ROR"},{"uri":"263100125","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"Prediction"},{"keyword":"alteration"},{"keyword":"response to cognitive and psychometric tests"},{"keyword":"seven years"},{"keyword":"predictive factors"},{"keyword":"cardiovascular risk"}],"topics":[{"topic":"Cardiology and vascular medicine","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/4455c187-2f2f-4cd1-a4dd-449f59d73b39"},{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/c42fc6ec-b216-4a24-9e9d-f5e781c175a0"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D002309"}]},{"topic":"Geriatrics","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/d37e4d8c-a978-40c7-ba4f-eee841851073"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D005853"}]},{"topic":"Neurology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/c4793dfe-e80e-49dd-9fcc-a1a742de1b25"},{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/00a5c4f4-b7ee-41a4-bcdf-3a02e6be1660"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D009462"}]},{"topic":"COVID-19","vocab":"cim-11","extLink":[{"uri":"http:\/\/id.who.int\/icd\/entity\/1730556128","title":"CIM-11"}]},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Behavioral determinants: Eating habits","vocab":"health determinant"}],"purpose":"Main objectives: - To identify predictors of impaired response to psychometric and cognitive tests and an altered level of cardiovascular risk over a period of seven years. - To develop corresponding risk prediction formulas. Secondary objectives: - To compare responses to psychometric and cognitive tests according to age. - To assess the prevalence of fragility syndrome according to age. - To assess the prevalence of dependency in subjects over 60 years old. - To identify predictive factors of the onset of fragility syndrome or dependency from a follow-up initiated in 2012. - On a sub-sample of 500 subjects that have undergone cerebral imaging (PET scan + MRI): - To assess the prevalence of the presence of cerebral amyloid deposits in the general population according to age. - To quantify the significance of cerebral amyloid deposits in terms of age. - To describe the relationship between cerebral amyloid deposits and response to psychometric and cognitive tests. - To identify factors associated with the presence of cerebral amyloid deposits.","abstract":"","coll_dates":[{"start":"2012-01-01","end":"2021-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Occitanie']","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Middle Aged (45 to 64 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n      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