{"doc_desc":{"title":"Cohorte des mineurs d'uranium en France","idno":"FRESH-PEF60014-fr","producers":[{"name":"Estelle RAGE","affiliation":"AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60014-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"60014"},{"agency":"FReSH","code":"FRESH-PEF60014"}]},"title":"Cohorte des mineurs d'uranium en France","alternate_title":"MINEURS D'URANIUM"},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"type":"investigator","name":"Dominique;LAURIER","PILabo":"LABORATOIRE D'\u00c9PID\u00c9MIOLOGIE DES RADIATIONS DRPH\/SRBE\/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURET\u00c9 NUCL\u00c9AIRE (IRSN)","affiliationName":"AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)","extlink":[{"title":"ORCID","uri":"0000-0003-1432-4738","role":"pi id"},{"title":"IdRef","uri":"156587181","role":"pi id"},{"title":"SIREN","uri":"130001803","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"dominique.laurier@irsn.fr","isContact":"Oui"},{"type":"investigator","name":"Klervi;LEURAUD","PILabo":"LABORATOIRE D'\u00c9PID\u00c9MIOLOGIE DES RADIATIONS DRPH\/SRBE\/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURET\u00c9 NUCL\u00c9AIRE (IRSN)","affiliationName":"AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"090176804","role":"pi id"},{"title":"SIREN","uri":"130001803","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"klervi.leuraud@irsn.fr","isContact":"Oui"},{"type":"investigator","name":"Estelle;RAGE","PILabo":"LABORATOIRE D'\u00c9PID\u00c9MIOLOGIE DES RADIATIONS DRPH\/SRBE\/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURET\u00c9 NUCL\u00c9AIRE (IRSN)","affiliationName":"AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)","extlink":[{"title":"","uri":"","role":"pi 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(ASNR)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/04dbtaf18"},{"title":"SIREN","uri":"130001803"}]}]},"distribution_statement":{"contact":[{"name":"Dominique;LAURIER","email":"dominique.laurier@irsn.fr","type":"contact","affiliationName":"AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/04dbtaf18","role":"organisation id","title":"ROR"},{"uri":"130001803","role":"organisation id","title":"SIREN"}]},{"name":"Klervi;LEURAUD","email":"klervi.leuraud@irsn.fr","type":"contact","affiliationName":"AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/04dbtaf18","role":"organisation id","title":"ROR"},{"uri":"130001803","role":"organisation id","title":"SIREN"}]},{"name":"Estelle;RAGE","email":"estelle.rage@irsn.fr","type":"contact","affiliationName":"AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/04dbtaf18","role":"organisation id","title":"ROR"},{"uri":"130001803","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"poumon"},{"keyword":"radon"},{"keyword":"alpha-risk"},{"keyword":"d\u00e9c\u00e8s"},{"keyword":"cancer"},{"keyword":"tabac"},{"keyword":"sant\u00e9"},{"keyword":"environnement"}],"topics":[{"topic":"Oncologie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/5784b7f1-c7ce-49d9-9f38-aebcda0ff41d"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D008495"}]},{"topic":"Cardiologie et m\u00e9decine vasculaire","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/4455c187-2f2f-4cd1-a4dd-449f59d73b39"},{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/c42fc6ec-b216-4a24-9e9d-f5e781c175a0"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D002309"}]},{"topic":"Sant\u00e9 publique, environnementale et du travail","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/b533acc2-aff1-4c65-80ca-5d5bee865ba9"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D004778"}]},{"topic":"Pneumologie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/f6e18c52-6087-4662-904c-5c4b8174e40e"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D015272"}]},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Emploi","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Addictions","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques","vocab":"health determinant"}],"purpose":"\u00c9tude de l'augmentation du risque de cancer, notamment de cancer pulmonaire, apr\u00e8s une exposition chronique \u00e0 des rayonnements ionisants, notamment \u00e0 des \u00e9metteurs alpha (descendants du radon, poussi\u00e8res d'uranium). Prise en compte de cofacteurs professionnels et du tabagisme. Objectif secondaire : cette \u00e9tude de cohorte b\u00e9n\u00e9ficie d'une bonne qualit\u00e9 de l'enregistrement individuel annuel de l'exposition \u00e0 diff\u00e9rents canc\u00e9rig\u00e8nes, et a un suivi de longue dur\u00e9e (plus de 20 ans en moyenne). L'ensemble des causes de d\u00e9c\u00e8s \u00e9tant enregistr\u00e9s r\u00e9guli\u00e8rement, il est possible d'\u00e9tudier \u00e9galement les risques autres que cancer dans cette cohorte, notamment le risque de d\u00e9c\u00e8s cardio-vasculaire ou respiratoire.l'extrapolation du risque par unit\u00e9 d'exposition permet l'\u00e9valuation du risque aux faibles doses, \u00e0 des niveaux rencontr\u00e9es r\u00e9guli\u00e8rement par une partie de la population fran\u00e7aise ; ceci est notamment vrai pour l'estimation du risque de cancer par unit\u00e9 d'exposition au radon dans les habitations.","abstract":"","coll_dates":[{"start":"1946-01-01","end":"2007-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Masculin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Adulte (19 \u00e0 24 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adulte (25 \u00e0 44 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Adulte (45 \u00e0 64 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Grand \u00e2ge (80 ans et plus)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Population g\u00e9n\u00e9rale\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Avoir travaill\u00e9 au moins 1 an dans les mines d'Uranium CEA-Areva\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es rapport\u00e9es par le participant de l'\u00e9tude']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":"['Pr\u00e9sence d\\'une requ\u00eate de coh\u00e9rence au moment de la saisie des donn\u00e9es informatiques et apr\u00e8s la saisie des donn\u00e9es informatiques.Gestion des donn\u00e9es manquantes par retour au dossier source.Croisements de l\\'ensemble des bases de donn\u00e9es disponibles.Relance des sujets pour r\u00e9aliser les visites de suivi.Audit qualit\u00e9 sur la gestion des bases de donn\u00e9es.IRSN : accr\u00e9ditation qualit\u00e9 ISO 9001.Les patients sont inform\u00e9s de l\\'utilisation de leur donn\u00e9es par \u00e9crit.']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de sant\u00e9\/morbidit\u00e9\r\nEv\u00e9nements de sant\u00e9\/mortalit\u00e9\r\nConsommation de soins\/services de sant\u00e9"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Base de population \u00e0 finalit\u00e9 statistique']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"SelfAdministeredQuestionnaire\",\"vocab\":\"CESSDA\"},\"value\":\"Questionnaire auto-administr\u00e9\"}","{\"concept\":{\"vocabURI\":\"Interview\",\"vocab\":\"CESSDA\"},\"value\":\"Entretien avec le participant (dont clinique)\"}"],"research_instrument":"Acc\u00e8s restreint sur projet sp\u00e9cifique","sources":[],"target_sample_size":"[1000-10000[ individus","response_rate":"5 086"},"method_notes":"Etude observationnelle","study_class":"Inconnu","notes":[{"subject":"research type","values":["Etude observationnelle"]},{"subject":"observational study 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of publications in HAL","link":"http:\/\/tinyurl.com\/HAL-Mineurs-d-uranium"}],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (Europe)","Industrie","Public (France)"],"otherFundingAgentType":["","",""]},"sponsor":{"sponsorType":["Industrie"],"otherSponsorType":[""]},"governance":{"committee":""},"collaborations":{"networkConsortium":"Oui"},"theme":{"complementaryInformation":"","RareDiseases":""},"activeFollowUp":{"isActiveFollowUp":"Oui","followUpModeOther":""},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":"","allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[],"inclusionGroups":[],"collectionProcess":{"collectionModeDetails":"Auto-questionnaire : saisie manuelle \u00e0 partir d\u2019un questionnaire papier.Entretiens : saisie manuelle \u00e0 partir d\u2019un questionnaire papier.","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":"Non"},"geographicalCoverage":{"geoDetail":"4 centres fran\u00e7ais (Mines de Vend\u00e9e, Limousin, H\u00e9rault, Forez)"},"dataTypes":{"clinicalDataDetails":"","biologicalDataDetails":"","isDataInBiobank":"Non","biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[]},"isHealthTheme":"Oui","fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}