{"doc_desc":{"title":"Cohorte de patients normo-tendus et hypertendus\/\u00e9valuation de l\u2019influence des facteurs faisant \u00e9voluer de la rigidit\u00e9 art\u00e9rielle","idno":"FRESH-PEF60044-fr","producers":[{"name":"Athanase BENETOS","affiliation":"chu"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60044-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"60044"},{"agency":"FReSH","code":"FRESH-PEF60044"}]},"title":"Cohorte de patients normo-tendus et hypertendus\/\u00e9valuation de l\u2019influence des facteurs faisant \u00e9voluer de la rigidit\u00e9 art\u00e9rielle","alternate_title":"ERA\/Evolution de la Rigidit\u00e9 Art\u00e9rielle"},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"type":"investigator","name":"Athanase;BENETOS","PILabo":"CHU \/ U961 INSERM","affiliationName":"chu","extlink":[{"title":"ORCID","uri":"0000-0002-5197-1515","role":"pi id"},{"title":"IdRef","uri":"074796151","role":"pi id"},{"title":"SIREN","uri":"200042166","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"a.benetos@chru-nancy.fr","isContact":"Oui"}],"oth_id":[{"name":"","type":""},{"name":"","type":""}],"production_statement":{"prod_place":"Portail Epid\u00e9miologie France (PEF)","producers":[{"name":"CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE NANCY","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/016ncsr12","role":"sponsor id"},{"title":"SIREN","uri":"200042166","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"FONDATION DE FRANCE","extlink":[{"title":"SIREN","uri":"784314908"}]},{"name":"FONDATION POUR LA RECHERCHE MEDICALE","extlink":[{"title":"SIREN","uri":"784314064"}]},{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261"},{"title":"SIREN","uri":"180036048"}]}]},"distribution_statement":{"contact":[{"name":"Athanase;BENETOS","email":"a.benetos@chru-nancy.fr","type":"contact","affiliationName":"chu","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/016ncsr12","role":"organisation id","title":"ROR"},{"uri":"200042166","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"plaques carotidiennes"},{"keyword":"rigidit\u00e9 art\u00e9rielle"},{"keyword":"hypertrophie art\u00e9rielle"},{"keyword":"environnement"}],"topics":[{"topic":"Cardiologie et m\u00e9decine vasculaire","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/4455c187-2f2f-4cd1-a4dd-449f59d73b39"},{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/c42fc6ec-b216-4a24-9e9d-f5e781c175a0"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D002309"}]},{"topic":"D\u00e9terminants biologiques : Pr\u00e9dispositions g\u00e9n\u00e9tiques","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques","vocab":"health determinant"}],"purpose":"Objectif g\u00e9n\u00e9ral : \u00e9valuer l\u2019influence des facteurs h\u00e9modynamiques, biologiques, environnementaux, ainsi que celle des d\u00e9terminants g\u00e9n\u00e9tiques, sur l\u2019\u00e9volution de la rigidit\u00e9 art\u00e9rielle chez des sujets normo-tendus et hypertendus. Une premi\u00e8re \u00e9valuation a \u00e9t\u00e9 r\u00e9alis\u00e9e \u00e0 moyen terme apr\u00e8s 6 ans de suivi sur 680 patients (1998-1999). Une deuxi\u00e8me \u00e9valuation \u00e0 long terme est pr\u00e9vue pour l'ann\u00e9e 2008-2009 c.-\u00e0-d. 10 ans apr\u00e8s la pr\u00e9c\u00e9dente \u00e9valuation. Objectifs secondaires : - \u00c9tudier les d\u00e9terminants h\u00e9modynamique, biologiques et g\u00e9n\u00e9tiques de l'attrition t\u00e9lom\u00e9riques (d\u00e9terminant cellulaire du vieillissement) sur une p\u00e9riode de 10 ans (entre 1999 et 2009) - \u00c9tablir la relation entre la rigidit\u00e9 art\u00e9rielle, l\u2019hypertrophie pari\u00e9tale et les plaques carotidiennes au cours des diff\u00e9rentes visites.","abstract":"","coll_dates":[{"start":"1992-01-01","end":"2009-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Ile-de-France']","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Masculin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Adulte (19 \u00e0 24 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adulte (25 \u00e0 44 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Adulte (45 \u00e0 64 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Sujets normo-tendus et hypertendus recrut\u00e9s et examin\u00e9s au centre d'investigations pr\u00e9ventives et cliniques de Paris (IPC- centre d'examens de sant\u00e9 conventionn\u00e9 par la s\u00e9curit\u00e9 sociale et la CNAM) dans le cadre du bilan\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es cliniques','Donn\u00e9es rapport\u00e9es par le participant de l'\u00e9tude','Donn\u00e9es paracliniques','Donn\u00e9es biologiques','Donn\u00e9es paracliniques (hors biologiques) : Imagerie','Donn\u00e9es paracliniques (hors biologiques) : Exploration fonctionnelle']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":"['Pr\u00e9sence d\\'une requ\u00eate de coh\u00e9rence apr\u00e8s la saisie des donn\u00e9es informatiques']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de sant\u00e9\/morbidit\u00e9\r\nEv\u00e9nements de sant\u00e9\/mortalit\u00e9"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Via des structures (services ou \u00e9tablissements de sant\u00e9, \u00e9coles, entreprises\u2026)']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"Interview\",\"vocab\":\"CESSDA\"},\"value\":\"Entretien avec le participant (dont clinique)\"}"],"research_instrument":"Acc\u00e8s restreint sur projet sp\u00e9cifique","sources":[],"target_sample_size":"[500-1000[ individus","response_rate":"680"},"method_notes":"Etude observationnelle","study_class":"Inconnu","notes":[{"subject":"research type","values":["Etude observationnelle"]},{"subject":"observational study method","values":["Cohorte"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Acc\u00e8s 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