{"doc_desc":{"title":"Cohorte en population g\u00e9n\u00e9rale : rythme cardiaque, baror\u00e9flexe, vieillissement art\u00e9riel, biomarqueurs et morbimortalit\u00e9 cardiovasculaire","idno":"FRESH-PEF60095-fr","producers":[{"name":"Jean-Philippe EMPANA","affiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60095-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"60095"},{"agency":"FReSH","code":"FRESH-PEF60095"}]},"title":"Cohorte en population g\u00e9n\u00e9rale : rythme cardiaque, baror\u00e9flexe, vieillissement art\u00e9riel, biomarqueurs et morbimortalit\u00e9 cardiovasculaire","alternate_title":"EPP 3 : \u00c9tude prospective parisienne 3"},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"type":"investigator","name":"Jean-Philippe;EMPANA","PILabo":"INSERM - Institut National de Sant\u00e9 et Recherche \/ U 970 INSERM","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE 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theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/4455c187-2f2f-4cd1-a4dd-449f59d73b39"},{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/c42fc6ec-b216-4a24-9e9d-f5e781c175a0"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D002309"}]},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques : Pr\u00e9dispositions g\u00e9n\u00e9tiques","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Alimentation","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9 : Consommation des soins","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Emploi","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9","vocab":"health determinant"}],"purpose":"Objectif g\u00e9n\u00e9ral : Identifier de nouveaux marqueurs de maladies cardiovasculaires et d'arr\u00eat cardiaque incluant des param\u00e8tres du rythme cardiaque et de sensibilit\u00e9 du baror\u00e9flexe, du vieillissement art\u00e9riel, et des biomarqueurs plasmatiques","abstract":"","coll_dates":[{"start":"2008-01-01","end":"2012-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Ile-de-France']","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Masculin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Adulte (45 \u00e0 64 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Population g\u00e9n\u00e9rale\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Hommes et femmes de 50 \u00e0 75 ans, du r\u00e9gime g\u00e9n\u00e9ral et consultant pour un bilan de sant\u00e9 au centre d'investigation pr\u00e9ventives et cliniques de Paris, volontaires pour l\u2019\u00e9tude (consentement \u00e9crit), comprenant le fran\u00e7ais et acceptant des analyses g\u00e9n\u00e9tiques\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es cliniques','Donn\u00e9es rapport\u00e9es par le participant de l'\u00e9tude','Donn\u00e9es paracliniques','Donn\u00e9es biologiques','Donn\u00e9es socio-d\u00e9mographiques','Donn\u00e9es paracliniques (hors biologiques) : Imagerie','Donn\u00e9es paracliniques (hors biologiques) : Exploration fonctionnelle']","quality_statement":{"standards":[{"name":"['code ATC pour les m\u00e9dicaments; code CIM10 pour les \u00e9v\u00e8nements cliniques']","committee":"","governance":""}],"other_quality_statement":"['Requ\u00eates de coh\u00e9rence pour les valeurs aberrantes, stabilit\u00e9 des informations recueillies au cours du suivi; audit de l\\'INSERM au cours du recrutement']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de 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