{"doc_desc":{"title":"Cohort of Long-Term Asymptomatic Subjects Infected with HIV","idno":"FRESH-PEF60151-en","producers":[{"name":"Brigitte AUTRAN","affiliation":"AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60151-en","IDno":{"metadata_no":[{"agency":"PEF","code":"60151"},{"agency":"FReSH","code":"FRESH-PEF60151"}]},"title":"Cohort of Long-Term Asymptomatic Subjects Infected with HIV","alternate_title":"ANRS CO15 ALT"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Brigitte;AUTRAN","PILabo":"Agence Nationale de Recherches sur le Sida et les h\u00e9patites virales \/ LABORATOIRE D'IMMUNOLOGIE CELLULAIRE ET ET TISSULAIRE SERVICE DU PR DEBR\u00c9 INSERM UMR-S 945 IMMUNIT\u00c9 ET INFECTION, IFR113","affiliationName":"AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"031517153","role":"pi id"},{"title":"SIREN","uri":"180089385","role":"organisation id"},{"title":"RNSR","uri":"200219822S","role":"labo id"}],"email":"brigitte.autran@sante.gouv.fr","isContact":"Yes"}],"oth_id":[{"name":"","type":""},{"name":"","type":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01kv58h76","role":"sponsor id"},{"title":"SIREN","uri":"180089385","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01kv58h76"},{"title":"SIREN","uri":"180089385"}]}]},"distribution_statement":{"contact":[{"name":"Brigitte;AUTRAN","email":"brigitte.autran@sante.gouv.fr","type":"contact","affiliationName":"AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/01kv58h76","role":"organisation id","title":"ROR"},{"uri":"180089385","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"follow-up"},{"keyword":"Health episodes"},{"keyword":"infection"}],"topics":[{"topic":"Clinical immunology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/7a3cf568-46ba-4840-be8f-f22fc030139f"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D000486"}]},{"topic":"Infectious disease medicine","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/fa2ceeab-3b2f-45e9-9243-e5a8005b98de"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D055552"}]},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"}],"purpose":"General objective: To define virus and host parameters associated with asymptomatic clinical status for 8 years or more following HIV infection. Secondary objective: HIV molecular characterisation, viral co-infections (HCV, CMV, HHV-8 ...); genetics and host immune response: CD4 T and anti-HIV CD8; anti-HIV antibodies and neutralising Ac; innate immunity, immune response to co-infections.","abstract":"","coll_dates":[{"start":"1994-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Young Adult (19 to 24 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adult (25 to 44 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Middle Aged (45 to 64 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Aged (65 to 79 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Aged, 80 and over (80 years and more)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Men or women over 18 years old, homosexual or bisexual, withdrawing addicts, individuals who have undergone transfusions or haemophiliacs, seropositive for at least 8 years, receiving no antiretroviral treatment, (stage II) or (stage III), with a CD4 count above 20% and 600\\\/mm3 (more or less 10%) with a stable or increasing count over a minimum of 3 examinations during the last 5 years, who have given signed and clear consent.\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Clinical data','Biological 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individuals","response_rate":"71"},"method_notes":"Observational Study","study_class":"Unknown","notes":[{"subject":"research type","values":["Observational Study"]},{"subject":"observational study method","values":["Cohort study"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Restricted access\",\"extLink\":[{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"}]}"},"dataset_use":{"restrictions":"Data may be used by academic teams To be decided if data may be used by industrial teams.","conditions":"","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":""}],"deposit_req":"","cit_req":""},"notes":""}},"additional":{"IsImport":true,"versionLang":"en","originLang":"en","autoTranslation":false,"status":"imported","creationDate":"08-03-2013","lastUpdatedAuto":null,"lastUpdatedManual":"12-08-2014","isContributorPI":"No","contributorName":"Brigitte AUTRAN","contributorAffiliation":"AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE)","addTeamMember":"","obtainedAuthorization":{"otherAuthorizingAgency":[]},"relatedDocument":[{"type":"","title":"List of publications in Pubmed","link":"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=ANRS+CO15"}],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)"],"otherFundingAgentType":[""]},"sponsor":{"sponsorType":["Public 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