{"doc_desc":{"title":"Cohort of 1,000 Households for H1N1 Pandemic Follow-Up","idno":"FRESH-PEF60168-en","producers":[{"name":"Fabrice CARRAT","affiliation":"SORBONNE UNIVERSITE"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60168-en","IDno":{"metadata_no":[{"agency":"PEF","code":"60168"},{"agency":"FReSH","code":"FRESH-PEF60168"}]},"title":"Cohort of 1,000 Households for H1N1 Pandemic Follow-Up","alternate_title":"COPANFLU"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Antoine;FLAHAULT","PILabo":"EHESP \/ ECOLE DES HAUTES ETUDES EN SANT\u00c9 PUBLIQUE","affiliationName":"ECOLE DES HAUTES ETUDES EN SANTE PUBLIQUE (EHESP)","extlink":[{"title":"ORCID","uri":"0000-0002-6957-2977","role":"pi id"},{"title":"IdRef","uri":"035602031","role":"pi id"},{"title":"SIREN","uri":"130003627","role":"organisation id"},{"title":"RNSR","uri":"201521285A","role":"labo id"}],"email":"antoine.flahault@unige.ch","isContact":"Yes"},{"type":"investigator","name":"Fabrice;CARRAT","PILabo":"Universit\u00e9 Paris 6 et \/ UMR-S 707 - \u00c9pid\u00e9miologie, mod\u00e9lisation syst\u00e8mes d'information","affiliationName":"SORBONNE UNIVERSITE","extlink":[{"title":"ORCID","uri":"0000-0002-8672-7918","role":"pi id"},{"title":"IdRef","uri":"061656720","role":"pi id"},{"title":"SIREN","uri":"130023385","role":"organisation id"},{"title":"RNSR","uri":"201420917E","role":"labo id"}],"email":"fabrice.carrat@iplesp.upmc.fr","isContact":"Yes"}],"oth_id":[{"name":"","type":""},{"name":"","type":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"ECOLE DES HAUTES ETUDES EN SANTE PUBLIQUE (EHESP)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01sc83v92","role":"sponsor id"},{"title":"SIREN","uri":"130003627","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"ECOLE DES HAUTES ETUDES EN SANTE PUBLIQUE (EHESP)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01sc83v92"},{"title":"SIREN","uri":"130003627"}]},{"name":"INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/05q3vnk25"},{"title":"SIREN","uri":"180006025"}]}]},"distribution_statement":{"contact":[{"name":"Antoine;FLAHAULT","email":"antoine.flahault@unige.ch","type":"contact","affiliationName":"ECOLE DES HAUTES ETUDES EN SANTE PUBLIQUE (EHESP)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/01sc83v92","role":"organisation id","title":"ROR"},{"uri":"130003627","role":"organisation id","title":"SIREN"}]},{"name":"Fabrice;CARRAT","email":"fabrice.carrat@iplesp.upmc.fr","type":"contact","affiliationName":"SORBONNE UNIVERSITE","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02en5vm52","role":"organisation id","title":"ROR"},{"uri":"130023385","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"influenza A (H1N1)"},{"keyword":"infectious respiratory syndromes"},{"keyword":"Health episodes"},{"keyword":"infections"},{"keyword":"complications"},{"keyword":"infection"}],"topics":[{"topic":"Infectious disease medicine","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/fa2ceeab-3b2f-45e9-9243-e5a8005b98de"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D055552"}]},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Environmental determinants: Other","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"},{"topic":"Environmental determinants","vocab":"health determinant"}],"purpose":"General objective: To identify individual epidemiological, environmental, immunological, social, genetic and virological risk determinants of infection by influenza A (H1N1) swine-like-(SWL) virus Secondary Objectives: - to describe the impact on public health in terms of morbidity, complications and health care resources for A (H1N1)-SWL infection; - to characterise the \u201cnatural\u201d history of the infection and its variability, to determine how it is transmitted; - to study the individual and collective determinants of the variable clinical expressions of the infection; - to study behavioural changes induced by pandemic and assess the level of risk perception and its evolution over time; - to evaluate penetrance, application and effectiveness of control measures in place (treatment, vaccination, barriers); - to characterise the homeotypic and heterotypic immunity of participants, according to age \u2013 evaluate herd immunity and to study innate and acquired cellular immunity subsequent to infection by this virus; - To characterise viral diversity and evolutionary mechanisms of virus A (H1N1)-SWL; to study the onset of drug resistance - to build and test anticipation models in real time on the impact of pandemic on the population and to simulate different control scenarios.","abstract":"","coll_dates":[{"start":"2009-01-01","end":"2012-01-01"}],"nation":[{"name":"Bolivia, Plurinational State of","abbreviation":"bo","extLink":{"vocab":"ISO","vocabURI":"bo"}},{"name":"Lao People's Democratic Republic","abbreviation":"la","extLink":{"vocab":"ISO","vocabURI":"la"}},{"name":"Mali","abbreviation":"ml","extLink":{"vocab":"ISO","vocabURI":"ml"}},{"name":"Cameroon","abbreviation":"cm","extLink":{"vocab":"ISO","vocabURI":"cm"}},{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Infant, Newborn (birth to 28 days)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D007231\"\n            }\n        },\n        {\n            \"value\": \"Infant (28 days to 2 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D007223\"\n            }\n        },\n        {\n            \"value\": \"Child, Preschool (2 to 5 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D002675\"\n            }\n        },\n        {\n            \"value\": \"Child (6 to 12 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D002648\"\n            }\n        },\n        {\n            \"value\": \"Young Adult (19 to 24 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adult (25 to 44 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Middle Aged (45 to 64 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Aged (65 to 79 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Aged, 80 and over (80 years and more)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"General population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Volunteer households in the metropolitan area whose members have all provided validated consent to participate in this cohort (Parental consent as well as children's is required, optional if they are over 7 years old and obligatory if they are over 13 years); covered by health insurance; can write and speak French and who have a land-line telephone.\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Participant-reported health data','Biological data']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Health event\/morbidity\r\nHealth event\/mortality"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Other\"}']","sample_frame":{"frame_unit":{"unit_type":"['Population database for statistical purposes']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"SelfAdministeredQuestionnaire\",\"vocab\":\"CESSDA\"},\"value\":\"Self-administered questionnaire\"}","{\"concept\":{\"vocabURI\":\"Interview\",\"vocab\":\"CESSDA\"},\"value\":\"Interview with the participant (including clinical)\"}"],"research_instrument":"Access on specific project only","sources":[],"target_sample_size":"[1000-10000[ individuals","response_rate":"1451"},"method_notes":"Observational Study","study_class":"Unknown","notes":[{"subject":"research type","values":["Observational Study"]},{"subject":"observational study method","values":["Cohort study"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Restricted access\",\"extLink\":[{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"}]}"},"dataset_use":{"restrictions":"","conditions":"According to IRESP Charter and INSERM\/EHESP convention","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":""}],"deposit_req":"","cit_req":""},"notes":""}},"additional":{"IsImport":true,"versionLang":"en","originLang":"en","autoTranslation":false,"status":"imported","creationDate":"08-03-2013","lastUpdatedAuto":null,"lastUpdatedManual":"14-08-2014","isContributorPI":"No","contributorName":"Fabrice CARRAT","contributorAffiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","addTeamMember":"","obtainedAuthorization":{"otherAuthorizingAgency":[]},"relatedDocument":[{"type":"","title":"List of publications in HAL","link":"http:\/\/www.hal.inserm.fr\/COPANFLU"}],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)","Public (France)"],"otherFundingAgentType":["",""]},"sponsor":{"sponsorType":["Public (France)"],"otherSponsorType":[""]},"governance":{"committee":""},"collaborations":{"networkConsortium":""},"theme":{"complementaryInformation":"","RareDiseases":""},"activeFollowUp":{"isActiveFollowUp":"Yes","followUpModeOther":""},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":"","allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[],"inclusionGroups":[],"collectionProcess":{"collectionModeDetails":"Self-administered questionnaire: input from a paper questionnaire with double data entry Interview: input from a paper questionnaire with double data entry Biological analysis: direct input","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":"No"},"geographicalCoverage":{"geoDetail":"International Study involving: Bolivia, Laos, Mali, Cameroon (not limited) Geographical area covered: National (France protocol)"},"dataTypes":{"clinicalDataDetails":"","biologicalDataDetails":"Type of samples taken: cells samples and and serum At baseline, after possible vaccination and twice a year","isDataInBiobank":"Yes","biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[]},"isHealthTheme":"Yes","fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}