{"doc_desc":{"title":"CADASIL patient cohort","idno":"FRESH-PEF60170-en","producers":[{"name":"Hugues CHABRIAT","affiliation":"ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60170-en","IDno":{"metadata_no":[{"agency":"PEF","code":"60170"},{"agency":"FReSH","code":"FRESH-PEF60170"}]},"title":"CADASIL patient cohort","alternate_title":"CADASIL"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Hugues;CHABRIAT","PILabo":"APHP \/ CERVCO CENTRE DE R\u00c9F\u00c9RENCES POUR LES MALADIES RARES DES VAISSEAUX DU CERVEAU ET DE L'OEIL, HOPITAL LARIBOISIERE","affiliationName":"ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP)","extlink":[{"title":"ORCID","uri":"0000-0001-8436-6074","role":"pi id"},{"title":"IdRef","uri":"060577304","role":"pi id"},{"title":"SIREN","uri":"267500452","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"hugues.chabriat@aphp.fr","isContact":"Yes"}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/00pg5jh14","role":"sponsor id"},{"title":"SIREN","uri":"267500452","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"association DE RECHERCHE EN NEUROLOGIE VASCULAIRE (ARNEVA)","extlink":[{"title":"SIREN","uri":"489698373"}]},{"name":"CADASIL FRANCE","extlink":[{"title":"SIREN","uri":"438378796"}]},{"name":"MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01wp0c315"},{"title":"SIREN","uri":"130016546"}]},{"name":"CENTRE DE MALADIES RARES","extlink":[]}]},"distribution_statement":{"contact":[{"name":"Hugues;CHABRIAT","email":"hugues.chabriat@aphp.fr","type":"contact","affiliationName":"ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/00pg5jh14","role":"organisation id","title":"ROR"},{"uri":"267500452","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"cognitive decline"},{"keyword":"mobility impairment"},{"keyword":"migraine"},{"keyword":"ischaemic stroke"},{"keyword":"epileptic seizure"},{"keyword":"Health episodes"},{"keyword":"apathy"},{"keyword":"hospitalisation"},{"keyword":"health system"}],"topics":[{"topic":"Neurology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/c4793dfe-e80e-49dd-9fcc-a1a742de1b25"},{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/00a5c4f4-b7ee-41a4-bcdf-3a02e6be1660"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D009462"}]},{"topic":"Socio-demographic and economic determinants: Employment","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"}],"purpose":"General objective: prospective study of patients with Notch 3 gene mutation thought to cause CADASIL: research into prognostic factors and useful markers for preventative treatment trial. 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        \"value\": \"Aged, 80 and over (80 years and more)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Adult patients with Notch 3 genetic mutation thought to cause CADASIL\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Clinical data','Biological data','Paraclinical data (non-biological) : Imaging']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Health event\/morbidity\r\nHealth 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