{"doc_desc":{"title":"Biological collection of primitive liver tumours","idno":"FRESH-PEF73056-en","producers":[{"name":"Jean-Fr\u00e9d\u00e9ric BLANC","affiliation":"CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF73056-en","IDno":{"metadata_no":[{"agency":"PEF","code":"73056"},{"agency":"FReSH","code":"FRESH-PEF73056"}]},"title":"Biological collection of primitive liver tumours","alternate_title":""},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Charles;BALABAUD","PILabo":"CHU Bordeaux \/ Hepatogastroenterology department, H\u00f4pital St Andr\u00e9","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"095620974","role":"pi id"},{"title":"SIREN","uri":"263305823","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"charles.balabaud@u-bordeaux.fr","isContact":"Yes"},{"type":"investigator","name":"Jean-Fr\u00e9d\u00e9ric;BLANC","PILabo":"CHU Bordeaux \/ h\u00e9pato-canc\u00e9ro","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"095620737","role":"pi id"},{"title":"SIREN","uri":"263305823","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"jean-frederic.blanc@chu-bordeaux.fr","isContact":"Yes"},{"type":"investigator","name":"Genevi\u00e8ve;CHENE","PILabo":"ISPED, Inserm","affiliationName":"UNIVERSITE DE BORDEAUX","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"059409401","role":"pi id"},{"title":"SIREN","uri":"130018351","role":"organisation id"},{"title":"","uri":"","role":"labo id"}],"email":"genevieve.chene@isped.u-bordeaux.fr","isContact":"Yes"}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01hq89f96","role":"sponsor id"},{"title":"SIREN","uri":"263305823","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261"},{"title":"SIREN","uri":"180036048"}]},{"name":"MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01wp0c315"},{"title":"SIREN","uri":"130016546"}]}]},"distribution_statement":{"contact":[{"name":"Charles;BALABAUD","email":"charles.balabaud@u-bordeaux.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/01hq89f96","role":"organisation id","title":"ROR"},{"uri":"263305823","role":"organisation id","title":"SIREN"}]},{"name":"Jean-Fr\u00e9d\u00e9ric;BLANC","email":"jean-frederic.blanc@chu-bordeaux.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/01hq89f96","role":"organisation id","title":"ROR"},{"uri":"263305823","role":"organisation id","title":"SIREN"}]},{"name":"Genevi\u00e8ve;CHENE","email":"genevieve.chene@isped.u-bordeaux.fr","type":"contact","affiliationName":"UNIVERSITE DE BORDEAUX","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/057qpr032","role":"organisation id","title":"ROR"},{"uri":"130018351","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"hepatic carcinogenesis"},{"keyword":"predictive markers"},{"keyword":"therapeutic target"},{"keyword":"tumour"},{"keyword":"liver"},{"keyword":"genetics"},{"keyword":"clinical and biological database"}],"topics":[{"topic":"Oncology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/5784b7f1-c7ce-49d9-9f38-aebcda0ff41d"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D008495"}]},{"topic":"Hepatology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/27c456a1-051a-42f6-b52a-3beff0487da7"}]},{"topic":"Malignant neoplasm of liver","vocab":"cim-11","extLink":[{"uri":"http:\/\/id.who.int\/icd\/entity\/1605020868","title":"CIM-11"}]},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"}],"purpose":"The purpose of creating this clinical and biological database is to: - increase the knowledge of genes and gene networks involved in the onset and progression of the represented liver tumours improve the knowledge of hepatic carcinogenesis mechanisms for fundamental research identify predictive markers of their potential for progression and their recurrence and identify new therapeutic targets for clinical research","abstract":"","coll_dates":[{"start":"2003-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Young Adult (19 to 24 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adult (25 to 44 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Middle Aged (45 to 64 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Aged (65 to 79 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Aged, 80 and over (80 years and more)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"All benign hepatocellular tumours and all malignant hepatocellular tumours. For the first category, adenomas, adenomatoses, poorly classified tumours, and atypical focal nodular hyperplasias are the most investigated tumours, and for the second category, hepatocellular carcinoma, pretumoural nodular lesions (macronodules and dysplastic nodules) and cholangiocarcinoma are the most investigated. 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