{"doc_desc":{"title":"The Global Hypopituitary Control and Complications Study (HypoCCS)-A Global Observational Research Program","idno":"FRESH-PEF78-en","producers":[{"name":"","affiliation":""}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF78-en","IDno":{"metadata_no":[{"agency":"PEF","code":"78"},{"agency":"FReSH","code":"FRESH-PEF78"}]},"title":"The Global Hypopituitary Control and Complications Study (HypoCCS)-A Global Observational Research Program","alternate_title":"HypoCCS"},"study_authorization":{"agency":[]},"authoring_entity":[],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"LILLY FRANCE","extlink":[{"title":"SIREN","uri":"609849153","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE)","extlink":[{"title":"SIREN","uri":"609849153"}]}]},"distribution_statement":{"contact":[{"name":"","type":"contact"}]},"study_info":{"keywords":[{"keyword":"Somatotrope deficiency"},{"keyword":"adult"},{"keyword":"treatments"},{"keyword":"tolerance"},{"keyword":"quality of life"}],"topics":[{"topic":"Endocrinology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/d1dd1bac-5313-4ab3-837f-4acd3ec521a7"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D004704"}]},{"topic":"Healthcare system determinants: Use of care","vocab":"health determinant"},{"topic":"Healthcare system determinants","vocab":"health determinant"}],"purpose":"Primary objective: long-term follow-up of the clinical change and of the tolerance in patients with a somatotrope deficiency whether or not treated with somatropin (Umatrope\u00ae)","abstract":"","coll_dates":[{"start":"2003-01-01","end":"2013-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}},{"name":"Madagascar","abbreviation":"mg","extLink":{"vocab":"ISO","vocabURI":"mg"}},{"name":"C\u00f4te d'Ivoire","abbreviation":"ci","extLink":{"vocab":"ISO","vocabURI":"ci"}},{"name":"Mali","abbreviation":"ml","extLink":{"vocab":"ISO","vocabURI":"ml"}},{"name":"Guinea","abbreviation":"gn","extLink":{"vocab":"ISO","vocabURI":"gn"}},{"name":"Bangladesh","abbreviation":"bd","extLink":{"vocab":"ISO","vocabURI":"bd"}},{"name":"Lebanon","abbreviation":"lb","extLink":{"vocab":"ISO","vocabURI":"lb"}}],"geog_coverage":"","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Young Adult (19 to 24 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adult (25 to 44 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Middle Aged (45 to 64 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Aged (65 to 79 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Adult patients suffering from growth hormone deficiency secondary to a hypothalamic  or pituitary disease appearing in adulthood or suffering from a growth hormone deficiency since childhood, - 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