{"doc_desc":{"title":"International Study of Asthma and Allergies in Childhood in France","idno":"FRESH-PEF8272-en","producers":[{"name":"Isabella ANNESI-MAESANO","affiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF8272-en","IDno":{"metadata_no":[{"agency":"PEF","code":"8272"},{"agency":"FReSH","code":"FRESH-PEF8272"}]},"title":"International Study of Asthma and Allergies in Childhood in France","alternate_title":"ISAAC"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Isabella;ANNESI-MAESANO","PILabo":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale \/ U1136 INSTITUT PIERRE LOUIS D'EPIDEMIOLOGIE ET DE SANTE PUBLIQUE (IPLESP)","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ORCID","uri":"0000-0002-6340-9300","role":"pi id"},{"title":"IdRef","uri":"123241847","role":"pi id"},{"title":"SIREN","uri":"180036048","role":"organisation id"},{"title":"RNSR","uri":"201420917E","role":"labo id"}],"email":"isabella.annesi-maesano@inserm.fr","isContact":"Yes"}],"oth_id":[{"name":"During ECHRS paediatrics. The project involves six hospital departments (Clermont-Ferrand, Marseille, Bordeaux, Reims, Strasbourg, Paris) and three specialist teams: \u2022 epidemiology team: Dr I. Annesi-Maesano, G. Debotte, INSERM U 472), \u2022 paediatric team: Prof. P. Scheinman, Dr. C. Karila, Dr. E. Paty (Necker-Enfants Malades Hospital, Paris); \u2022 metrology team: M. Squinazi, Y. Le Moullec, M. Laurent (laboratoire d\u2019hygi\u00e8ne de la ville de Paris [The City of Paris Hygiene Laboratory]).","type":"collaboration"}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"sponsor id"},{"title":"SIREN","uri":"180036048","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"AGENCE DE L ENVIRONNEMENT ET DE LA MAITRISE DE L ENERGIE (ADEME)","extlink":[{"title":"SIREN","uri":"385290309"}]},{"name":"FONDATION ENTREPRISE MGEN SANTE PUBLIQUE (FSP MGEN)","extlink":[{"title":"SIREN","uri":"444268627"}]},{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261"},{"title":"SIREN","uri":"180036048"}]},{"name":"MINISTERE DU TRAVAIL ET DES SOLIDARITES","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/018k53h31"},{"title":"SIREN","uri":"110000072"}]}]},"distribution_statement":{"contact":[{"name":"Isabella;ANNESI-MAESANO","email":"isabella.annesi-maesano@inserm.fr","type":"contact","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id","title":"ROR"},{"uri":"180036048","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"skin test"},{"keyword":"air pollution"},{"keyword":"child"},{"keyword":"environment"},{"keyword":"allergy"}],"topics":[{"topic":"Allergology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/af65e2bf-afc5-45e8-a0fc-364dfb48f0a4"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D000486"}]},{"topic":"Paediatrics","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/bf8aaaac-ddee-41cd-bb8a-c5a63de3fcbd"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D010372"}]},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Environmental determinants","vocab":"health determinant"},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"}],"purpose":"To establish a global map of the prevalence of childhood allergic diseases and to determine the risk factors for these diseases by comparing contrasting population groups based on a particularly strong or weak prevalence. The ISAAC study consists of three phases: The objective of Phase I is to assess the prevalence of asthma, allergic rhinitis and eczema by using a simple questionnaire and possible video questionnaire (for asthma), in representative samples of children from two age groups: 13-14 years old (obligatory for all centres) and 6-7 years old (optional). Phase II aims to identify the risk factors and treatment procedures for allergic diseases through a more detailed study of selected population groups with relatively high or low prevalence rates suggested during Phase I. Phase III aims to assess the trends in allergy prevalence. As such, the Phase I protocol will be repeated in areas that participated in this phase.","abstract":"","coll_dates":[{"start":"1999-01-01","end":"2000-01-01"}],"nation":[{"name":"Belize","abbreviation":"bz","extLink":{"vocab":"ISO","vocabURI":"bz"}},{"name":"China","abbreviation":"cn","extLink":{"vocab":"ISO","vocabURI":"cn"}},{"name":"Germany","abbreviation":"de","extLink":{"vocab":"ISO","vocabURI":"de"}},{"name":"Italy","abbreviation":"it","extLink":{"vocab":"ISO","vocabURI":"it"}},{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}},{"name":"Japan","abbreviation":"jp","extLink":{"vocab":"ISO","vocabURI":"jp"}},{"name":"Korea, Republic of","abbreviation":"kr","extLink":{"vocab":"ISO","vocabURI":"kr"}},{"name":"Taiwan, Province of China","abbreviation":"tw","extLink":{"vocab":"ISO","vocabURI":"tw"}},{"name":"Russian Federation","abbreviation":"ru","extLink":{"vocab":"ISO","vocabURI":"ru"}},{"name":"Spain","abbreviation":"es","extLink":{"vocab":"ISO","vocabURI":"es"}},{"name":"United Kingdom","abbreviation":"gb","extLink":{"vocab":"ISO","vocabURI":"gb"}},{"name":"United States","abbreviation":"us","extLink":{"vocab":"ISO","vocabURI":"us"}}],"geog_coverage":"","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Child (6 to 12 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D002648\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"General population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"primary school children - between 8 and 13 years old\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Clinical data','Participant-reported health data','Biological data','Paraclinical data (non-biological) : Anthropometry']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Health event\/morbidity"}]},"method":{"data_collection":{"time_method":"One-time cross-sectional study","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Other\"}']","sample_frame":{"frame_unit":{"unit_type":"['Population database for statistical purposes']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"MeasurementsAndTests.Physical\",\"vocab\":\"CESSDA\"},\"value\":\"Physical\/biological measurements (blood pressure, weight, biochemistry, imaging, etc.)\"}"],"research_instrument":"Access on specific project only","sources":[],"target_sample_size":"[1000-10000[ individuals","response_rate":"Monde\/World: 721 601 France: 7 432"},"method_notes":"Observational Study","study_class":"Completed study","notes":[{"subject":"research type","values":["Observational Study"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Restricted access\",\"extLink\":[{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"}]}"},"dataset_use":{"restrictions":"","conditions":"Contact the principal investigator","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":""}],"deposit_req":"","cit_req":""},"notes":""}},"additional":{"IsImport":true,"versionLang":"en","originLang":"en","autoTranslation":false,"status":"imported","creationDate":"04-03-2014","lastUpdatedAuto":null,"lastUpdatedManual":"05-09-2017","isContributorPI":"No","contributorName":"Isabella ANNESI-MAESANO","contributorAffiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","addTeamMember":"","obtainedAuthorization":{"otherAuthorizingAgency":[]},"relatedDocument":[{"type":"","title":"","link":"http:\/\/erj.ersjournals.com\/content\/24\/3\/406.long"}],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)","Private non-profit","Public (France)","Public (France)"],"otherFundingAgentType":["","","",""]},"sponsor":{"sponsorType":["Public (France)"],"otherSponsorType":[""]},"governance":{"committee":""},"collaborations":{"networkConsortium":"Yes"},"theme":{"complementaryInformation":"","RareDiseases":""},"activeFollowUp":{"isActiveFollowUp":"No","followUpModeOther":""},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":"","allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[],"inclusionGroups":[],"collectionProcess":{"collectionModeDetails":"Pollutants measured in school yards and measurements collected by urban air quality monitoring networks: - SO2, FN, NOx, NO2, O3 and PM using collective measurements (city monitoring networks) (macroenvironment); - NOx, NO2, O3, VOC (formaldehyde) and PM using passive sensors within schools (microenvironment); - NO2, O3, COV. using individual badges as part of the panel (individual). Each centre can choose the protocol best suited to them. However, a minimum protocol was agreed at European level.","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":"No"},"geographicalCoverage":{"geoDetail":"One hundred and fifty-six centres in 56 countries: North America, Central America, South America, Western Europe, Central Europe (Albania, Germany, Estonia, Spain, France, Greece, Iceland, Italy, Norway, Netherlands , Portugal, U.K., Sweden), the Baltic States, Far East, Western Pacific, Anglophone Africa, Francophone Africa, Southeast Asia, East Mediterranean countries and Oceania. In France (primary schools in six French cities: Cr\u00e9teil, Clermont-Ferrand, Bordeaux, Marseille, Reims, Strasbourg)."},"dataTypes":{"clinicalDataDetails":"Allergy assessment: skin prick tests, Williams standardised skin test (eczema), free running test, with peak respiratory flow (bronchial hyper-reactivity).","biologicalDataDetails":"urine and hair cotinine research (nicotine metabolite), inflammation and lead markers","isDataInBiobank":"No","biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[]},"isHealthTheme":"Yes","fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}