{"doc_desc":{"title":"Karolinska-Rennes Cohort: Cardiac Dyssynchrony in Patients with Heart Failure and Preserved Ejection Fraction","idno":"FRESH-PEF8678-en","producers":[{"name":"Genevi\u00e8ve MULAK","affiliation":"SOC FRANCAISE DE CARDIOLOGIE"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF8678-en","IDno":{"metadata_no":[{"agency":"PEF","code":"8678"},{"agency":"FReSH","code":"FRESH-PEF8678"}]},"title":"Karolinska-Rennes Cohort: Cardiac Dyssynchrony in Patients with Heart Failure and Preserved Ejection Fraction","alternate_title":"KaRen"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Jean-Claude;DAUBERT","PILabo":"CHU \/ Centre Cardio-Pneumologique, H\u00f4pital Pontchaillou, CHU de Rennes","affiliationName":"chu","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"060362650","role":"pi id"},{"title":"ROR","uri":"https:\/\/ror.org\/05qec5a53","role":"organisation id"},{"title":"","uri":"","role":"labo 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\"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Young Adult (19 to 24 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adult (25 to 44 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        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major + 2 minor criteria; - LVEF (Left Ventricular Fraction) greater or equal to 45% by echocardiography; - NT-proBNP greater than 300 pg\\\/mL or BNP greater than 100.  \",\n    \"clusion_E\": \"Evidence of primary hypertrophic or restrictive cardiomyopathy, or systemic illness known to be associated with infiltrative heart disease; - Known right heart failure by pulmonary or pulmonary vascular disease not related to the left heart; - Pericardial constriction; - Restrictive or obstructive pulmonary disease, as evidenced by the requirement for home oxygen; - End-stage renal disease currently requiring dialysis; - Bi-ventricular pacemaker (CRT-P + ICD); - Acute coronary syndrome.\"\n}","data_kind":"['Clinical data','Participant-reported health data','Biological data','Paraclinical data (non-biological) : Function 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