{"doc_desc":{"title":"Etude cas-t\u00e9moins sur la pr\u00e9f\u00e9rence pour le sucre dans l'alcoolo-d\u00e9pendance","idno":"FRESH-PEF8912-fr","producers":[{"name":"Philip GORWOOD","affiliation":"CENTRE HOSPITALIER SAINTE ANNE PARIS"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF8912-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"8912"},{"agency":"FReSH","code":"FRESH-PEF8912"}]},"title":"Etude cas-t\u00e9moins sur la pr\u00e9f\u00e9rence pour le sucre dans l'alcoolo-d\u00e9pendance","alternate_title":"AGEPSA"},"study_authorization":{"agency":[{"name":"CNIL"},{"name":"CESREES"}]},"authoring_entity":[{"type":"investigator","name":"Philip;GORWOOD","PILabo":"GHU Paris \/ INSERM U1266","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"ORCID","uri":"0000-0003-1845-3676","role":"pi id"},{"title":"IdRef","uri":"070224455","role":"pi id"},{"title":"SIREN","uri":"267500643","role":"organisation id"},{"title":"RNSR","uri":"200816530M","role":"labo id"}],"email":"p.gorwood@ghu-paris.fr","isContact":"Oui"},{"type":"investigator","name":"Alexandra;DEREUX","PILabo":"Centre Hospitalier Saint","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"176481168","role":"pi id"},{"title":"SIREN","uri":"267500643","role":"organisation id"},{"title":"RNSR","uri":"200817366W","role":"labo id"}],"email":"alexandra.dereux@aphp.fr","isContact":"Oui"}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Portail Epid\u00e9miologie France (PEF)","producers":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"sponsor id"},{"title":"SIREN","uri":"180036048","role":"sponsor id"}],"role":"sponsor"},{"name":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02kxjxy06","role":"sponsor id"},{"title":"SIREN","uri":"267500643","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02kxjxy06"},{"title":"SIREN","uri":"267500643"}]},{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261"},{"title":"SIREN","uri":"180036048"}]}]},"distribution_statement":{"contact":[{"name":"Philip;GORWOOD","email":"p.gorwood@ghu-paris.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02kxjxy06","role":"organisation id","title":"ROR"},{"uri":"267500643","role":"organisation id","title":"SIREN"}]},{"name":"Alexandra;DEREUX","email":"alexandra.dereux@aphp.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02kxjxy06","role":"organisation id","title":"ROR"},{"uri":"267500643","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"Pr\u00e9f\u00e9rence"},{"keyword":"sucr\u00e9"},{"keyword":"sucrose"},{"keyword":"endoph\u00e9notype"},{"keyword":"alcoolo-d\u00e9pendance"},{"keyword":"cas-t\u00e9moin"},{"keyword":"appariement"},{"keyword":"pr\u00e9cocit\u00e9"},{"keyword":"s\u00e9v\u00e9rit\u00e9"},{"keyword":"ant\u00e9c\u00e9dents familiaux"},{"keyword":"sensation"},{"keyword":"impulsivit\u00e9"},{"keyword":"r\u00e9ponse h\u00e9doniques"},{"keyword":"vuln\u00e9rabilit\u00e9."}],"topics":[{"topic":"Endocrinologie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/d1dd1bac-5313-4ab3-837f-4acd3ec521a7"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D004704"}]},{"topic":"Psychiatrie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/3de50dee-da1c-4791-a386-56bca24a5fed"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D011570"}]},{"topic":"Addictologie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/42d645e0-f58d-40ed-9917-5b227ff41a92"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D000073316"}]},{"topic":"D\u00e9terminants comportementaux : Addictions","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques : Pr\u00e9dispositions g\u00e9n\u00e9tiques","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques","vocab":"health determinant"}],"purpose":"L' objectif principal est d\u2019\u00e9tudier si la pr\u00e9f\u00e9rence pour le sucr\u00e9 constitue un endoph\u00e9notype de l\u2019alcoolo-d\u00e9pendance, en v\u00e9rifiant que la pr\u00e9f\u00e9rence pour le sucr\u00e9 est plus fr\u00e9quente chez les sujets apparent\u00e9s au premier degr\u00e9 de sujets alcoolo-d\u00e9pendants que chez les contr\u00f4les. Les objectifs secondaires consistent \u00e0 \u00e9tudier les sp\u00e9cificit\u00e9s cliniques (pr\u00e9cocit\u00e9, s\u00e9v\u00e9rit\u00e9), familiales (pr\u00e9sence d\u2019ant\u00e9c\u00e9dents familiaux), temp\u00e9ramentales (recherche de sensation, impulsivit\u00e9) et cognitives (mesure de la r\u00e9ponse h\u00e9donique visuelle, t\u00e2ches d\u00e9cisionnelles \u00e0 l\u2019IGT) des sujets alcoolo-d\u00e9pendants ayant une pr\u00e9f\u00e9rence pour les solutions les plus concentr\u00e9es en sucrose, afin d\u2019explorer les m\u00e9canismes impliqu\u00e9s dans cette relation endoph\u00e9notypique et de tester les hypoth\u00e8ses suivantes : - soit la pr\u00e9f\u00e9rence pour les solutions les plus sucr\u00e9es est secondaire \u00e0 l\u2019alcoolo-d\u00e9pendance ; - soit la pr\u00e9f\u00e9rence pour le sucre est un marqueur de vuln\u00e9rabilit\u00e9 de l\u2019alcoolo-d\u00e9pendance (la pr\u00e9f\u00e9rence pour le sucr\u00e9 serait un marqueur d\u2019un sous-type d\u2019alcoolisme, associ\u00e9 \u00e0 une plus forte vuln\u00e9rabilit\u00e9 g\u00e9n\u00e9tique, proche du type clinique 2 d\u00e9crit par Cloninger).","abstract":"","coll_dates":[{"start":"2011-01-01","end":"2016-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Ile-de-France']","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Masculin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Adulte (19 \u00e0 24 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adulte (25 \u00e0 44 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Adulte (45 \u00e0 64 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \" individus \u00e2g\u00e9s de 18 \u00e0 65 ans - patients alcoolo-d\u00e9pendants* sevr\u00e9s depuis au moins une semaine (*selon les crit\u00e8res du DSM-IV) ; - t\u00e9moins expos\u00e9s \u00e0 la consommation d\u2019alcool mais ne pr\u00e9sentant pas de crit\u00e8res de d\u00e9pendance* ; - individus apparent\u00e9s au premier degr\u00e9 \u00e0 une personne d\u00e9pendante \u00e0 l\u2019alcool, sans crit\u00e8re de d\u00e9pendance personnelle*.  \",\n    \"clusion_E\": \"personnes pr\u00e9sentant un trouble du comportement alimentaire, un indice de masse corporelle inf\u00e9rieur \u00e0 18 ou sup\u00e9rieur \u00e0 30 ou un diab\u00e8te\"\n}","data_kind":"['Donn\u00e9es cliniques']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Autres"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Via des structures (services ou \u00e9tablissements de sant\u00e9, \u00e9coles, entreprises\u2026)']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"Transcription\",\"vocab\":\"CESSDA\"},\"value\":\"Transcription et saisie d\u2019informations dans un enregistrement structur\u00e9\"}","{\"concept\":{\"vocabURI\":\"Interview\",\"vocab\":\"CESSDA\"},\"value\":\"Entretien avec le participant (dont clinique)\"}"],"research_instrument":"Acc\u00e8s restreint sur projet sp\u00e9cifique","sources":[],"target_sample_size":"< 500 individus","response_rate":"30 patients\/cases, 30 contr\u00f4les et 30 apparent\u00e9s\/ controls)."},"method_notes":"Etude observationnelle","study_class":"Inconnu","notes":[{"subject":"research type","values":["Etude observationnelle"]},{"subject":"observational study method","values":["Etude cas-t\u00e9moins"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Acc\u00e8s r\u00e9serv\u00e9\",\"extLink\":[{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"}]}"},"dataset_use":{"restrictions":"","conditions":"Contacter le responsable scientifique","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":""}],"deposit_req":"","cit_req":""},"notes":""}},"additional":{"IsImport":true,"versionLang":"fr","originLang":"fr","autoTranslation":false,"status":"imported","creationDate":"14-05-2014","lastUpdatedAuto":null,"lastUpdatedManual":"07-09-2020","isContributorPI":"Non","contributorName":"Philip GORWOOD","contributorAffiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","addTeamMember":"","obtainedAuthorization":{"otherAuthorizingAgency":["",""]},"relatedDocument":[{"type":"","title":"","link":"http:\/\/www.ireb.com\/sites\/default\/files\/Cahiers%2021.pdf"}],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)","Public (France)"],"otherFundingAgentType":["",""]},"sponsor":{"sponsorType":["Public (France)","Public (France)"],"otherSponsorType":["",""]},"governance":{"committee":""},"collaborations":{"networkConsortium":""},"theme":{"complementaryInformation":"","RareDiseases":""},"activeFollowUp":{"isActiveFollowUp":"Non","followUpModeOther":""},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":"","allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[],"inclusionGroups":[],"collectionProcess":{"collectionModeDetails":"","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":"Non"},"geographicalCoverage":{"geoDetail":"Centre Hospitalier Sainte Anne (75014 Paris), Centre Hospitalier Corentin Celton (92130 Issy-les-Moulineaux), CHU Louis Mourier (92700 Colombes)."},"dataTypes":{"clinicalDataDetails":"- L\u2019\u00e9valuation de la r\u00e9ponse h\u00e9donique au sucre est r\u00e9alis\u00e9e gr\u00e2ce au Test au Go\u00fbt Sucr\u00e9 qui consiste \u00e0 pr\u00e9senter aux sujets six solutions de sucrose plus ou moins concentr\u00e9es (entre 0 et 0,84 M).Les sujets devaient pour chaque solution \u00e9valuer la concentration en sucre puis le plaisir ressenti \u00e0 l\u2019aide d\u2019\u00e9chelles visuelles analogiques. D\u00e9termination d'un \"sweet score\".Plusieurs tests cliniques et neurocognitifs compl\u00e8tent l\u2019\u00e9valuation, dont :- Un test visuel d\u2019h\u00e9donie informatis\u00e9 consistant \u00e0 faire coter le niveau de plaisir ressenti devant unes\u00e9rie de 40 photographies norm\u00e9es plus ou moins plaisantes de paysages ;- L\u2019Echelle d\u2019impulsivit\u00e9 de Barratt (BIS-11), auto-questionnaire \u00e9valuant l\u2019impulsivit\u00e9 selon trois facteurs : l\u2019impulsivit\u00e9 motrice, l\u2019impulsivit\u00e9 cognitive et la difficult\u00e9 de temporisation ;- L\u2019Hospital Anxiety and Depression Scale (HAD), auto-questionnaire mesurant l\u2019\u00e9tat d\u2019anxi\u00e9t\u00e9 et d\u2019humeur au moment de l\u2019\u00e9valuation (Zigmond et al., 1983)","biologicalDataDetails":"","isDataInBiobank":"Non","biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[]},"isHealthTheme":"Oui","fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}