{"doc_desc":{"title":"Case-Control Study on Sweetness Preference in Alcohol Dependence","idno":"FRESH-PEF8912-en","producers":[{"name":"Philip GORWOOD","affiliation":"CENTRE HOSPITALIER SAINTE ANNE PARIS"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF8912-en","IDno":{"metadata_no":[{"agency":"PEF","code":"8912"},{"agency":"FReSH","code":"FRESH-PEF8912"}]},"title":"Case-Control Study on Sweetness Preference in Alcohol Dependence","alternate_title":"AGEPSA"},"study_authorization":{"agency":[]},"authoring_entity":[{"type":"investigator","name":"Philip;GORWOOD","PILabo":"GHU Paris \/ INSERM U1266","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"ORCID","uri":"0000-0003-1845-3676","role":"pi id"},{"title":"IdRef","uri":"070224455","role":"pi id"},{"title":"SIREN","uri":"267500643","role":"organisation id"},{"title":"RNSR","uri":"200816530M","role":"labo id"}],"email":"p.gorwood@ghu-paris.fr","isContact":"Yes"},{"type":"investigator","name":"Alexandra;DEREUX","PILabo":"Centre Hospitalier Saint","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"","uri":"","role":"pi id"},{"title":"IdRef","uri":"176481168","role":"pi id"},{"title":"SIREN","uri":"267500643","role":"organisation id"},{"title":"RNSR","uri":"200817366W","role":"labo id"}],"email":"alexandra.dereux@aphp.fr","isContact":"Yes"}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"sponsor id"},{"title":"SIREN","uri":"180036048","role":"sponsor id"}],"role":"sponsor"},{"name":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02kxjxy06","role":"sponsor id"},{"title":"SIREN","uri":"267500643","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"CENTRE HOSPITALIER SAINTE ANNE PARIS","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02kxjxy06"},{"title":"SIREN","uri":"267500643"}]},{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261"},{"title":"SIREN","uri":"180036048"}]}]},"distribution_statement":{"contact":[{"name":"Philip;GORWOOD","email":"p.gorwood@ghu-paris.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02kxjxy06","role":"organisation id","title":"ROR"},{"uri":"267500643","role":"organisation id","title":"SIREN"}]},{"name":"Alexandra;DEREUX","email":"alexandra.dereux@aphp.fr","type":"contact","affiliationName":"CENTRE HOSPITALIER SAINTE ANNE PARIS","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02kxjxy06","role":"organisation id","title":"ROR"},{"uri":"267500643","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"preference"},{"keyword":"sweet"},{"keyword":"sugar"},{"keyword":"endophenotype"},{"keyword":"case-control"},{"keyword":"matching"},{"keyword":"precocity"},{"keyword":"impulsiveness"},{"keyword":"hedonic response"},{"keyword":"alcohol dependence"},{"keyword":"severity"},{"keyword":"family history"},{"keyword":"sensation"},{"keyword":"vulnerability"}],"topics":[{"topic":"Endocrinology","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/d1dd1bac-5313-4ab3-837f-4acd3ec521a7"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D004704"}]},{"topic":"Psychiatry","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/3de50dee-da1c-4791-a386-56bca24a5fed"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D011570"}]},{"topic":"Addiction medicine","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/42d645e0-f58d-40ed-9917-5b227ff41a92"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D000073316"}]},{"topic":"Behavioral determinants: Addiction","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"}],"purpose":"The main objective is to investigate the endophenotypic nature of sweet-liking in alcohol-dependence and to verify that the preference for sweetness is more common in subjects that are first-degree relatives of alcohol-dependent subjects than in control subjects. Secondary objectives include: studying specific clinical (precocity, severity), family (family history), temperamental (sensation seeking, impulsiveness) and cognitive traits (measurement of visual hedonic response, IGT decision-making tasks) in alcohol-dependent subjects that prefer the sweetest solutions; investigating the mechanisms involved in this endophenotypic connection and testing the following hypotheses: - Either the preference for the sweetest solutions is secondary to alcohol dependence; - Either the preference for sweetness is a marker of vulnerability to alcohol-dependence (sweetness preference would be a marker of an alcoholic sub-type associated with a higher genetic vulnerability that is close to Cloninger's clinical type 2 classification).","abstract":"","coll_dates":[{"start":"2011-01-01","end":"2016-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Ile-de-France']","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Young Adult (19 to 24 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adult (25 to 44 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Middle Aged (45 to 64 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Individuals aged between 18 and 65 years old; - Alcohol-dependent* patients that have been weaned for at least a week (according to DSM-IV criteria); - Control subjects exposed to alcohol consumption but who do not fulfil dependence criteria*; - Individuals that are first-degree relatives of an alcohol-dependent person with no personal dependence criterion*.  \",\n    \"clusion_E\": \"Individuals with an eating disorder, body mass index lower than 18 or greater than 30, or diabetes.\"\n}","data_kind":"['Clinical data']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Others"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Other\"}']","sample_frame":{"frame_unit":{"unit_type":"['Through organizations (health services or institutions, schools, businesses, etc.)']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"Transcription\",\"vocab\":\"CESSDA\"},\"value\":\"Converting or copying information into a structured record\"}","{\"concept\":{\"vocabURI\":\"Interview\",\"vocab\":\"CESSDA\"},\"value\":\"Interview with the participant (including clinical)\"}"],"research_instrument":"Access on specific project only","sources":[],"target_sample_size":"< 500 individuals","response_rate":"500 (300 patients\/cases, 100 controls and 100 relations\/controls)."},"method_notes":"Observational Study","study_class":"Unknown","notes":[{"subject":"research type","values":["Observational Study"]},{"subject":"observational study method","values":["Case-control study"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"Restricted access\",\"extLink\":[{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"}]}"},"dataset_use":{"restrictions":"","conditions":"Contact the scientist in charge for further information.","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":""}],"deposit_req":"","cit_req":""},"notes":""}},"additional":{"IsImport":true,"versionLang":"en","originLang":"en","autoTranslation":false,"status":"imported","creationDate":"14-05-2014","lastUpdatedAuto":null,"lastUpdatedManual":"07-09-2020","isContributorPI":"No","contributorName":"Philip GORWOOD","contributorAffiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","addTeamMember":"","obtainedAuthorization":{"otherAuthorizingAgency":[]},"relatedDocument":[{"type":"","title":"","link":"http:\/\/www.ireb.com\/sites\/default\/files\/Cahiers%2021.pdf"}],"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)","Public (France)"],"otherFundingAgentType":["",""]},"sponsor":{"sponsorType":["Public (France)","Public (France)"],"otherSponsorType":["",""]},"governance":{"committee":""},"collaborations":{"networkConsortium":""},"theme":{"complementaryInformation":"","RareDiseases":""},"activeFollowUp":{"isActiveFollowUp":"No","followUpModeOther":""},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":"","allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[],"inclusionGroups":[],"collectionProcess":{"collectionModeDetails":"","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":"No"},"geographicalCoverage":{"geoDetail":"Sainte Anne Hospital Centre (75014 Paris), Corentin Celton Hospital Centre (92130 Issy-les-Moulineaux), Louis Mourier UHC (92700 Colombes)."},"dataTypes":{"clinicalDataDetails":"- The hedonic response to sweetness is measured using the Sweet Taste Test. Subjects are offered six sweet solutions of varying concentrations (between 0 and 0.84 M). The subjects were asked to evaluate the sugar concentration of each solution and the pleasure experienced using visual analogue scales. \"Sweet Score\" determination. The assessment is supplemented by several clinical and neurocognitive tests, including: - a computer-based, visual hedonic response test to rate the level of pleasure experienced with a series of standardised pictures of various pleasant landscapes; - The Barratt Impulsiveness Scale (BIS-11), a self-administered questionnaire that assesses impulsiveness according to three factors: motor impulsiveness, cognitive impulsiveness and planning difficulty; - Hospital Anxiety and Depression Scale (HAD), self-assessment questionnaire measuring anxiety and mood at the time of the assessment (Zigmond et al., 1983).","biologicalDataDetails":"","isDataInBiobank":"No","biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[]},"isHealthTheme":"Yes","fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}