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<docDscr>
  <citation>
    <titlStmt>
      <titl>Efficacy of the Mode of Delivery of Autologous Bone Marrow Cells Into Heart Scar Muscle for the Recovery of Contractile Function</titl>
      <IDNo>FReSH-69759-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="" role="">Rémy Ben Messaoud</producer>
    </prodStmt>
    <verStmt>
      <version></version>
    </verStmt>
  </citation>
</docDscr>
<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Efficacy of the Mode of Delivery of Autologous Bone Marrow Cells Into Heart Scar Muscle for the Recovery of Contractile Function            </titl>
      <IDNo agency="FReSH-lang">
                FReSH-69759-en            </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
        <ExtLink title="ORCID" URI="null" role="pi id"/>
        <ExtLink title="IdRef" URI="null" role="pi id"/>
      </AuthEnty>
      <AuthEnty affiliation="University Hospitals, Leicester">
                                                                                                </AuthEnty>
      <AuthEnty>
        <ExtLink title="RNSR" URI="null" role="labo id"/>
      </AuthEnty>
      <othId affiliation="" type="contributor">
        <ExtLink title="ORCID" URI="" role="team member id"/>
        <ExtLink title="IdRef" URI="" role="team member id"/>
      </othId>
      <othId affiliation="" type="affiliation">
        <ExtLink title="RNSR" URI="" role="labo id"/>
      </othId>
      <othId affiliation="British Heart Foundation" type="collaboration">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            University Hospitals, Leicester                    
                                    </producer>
      <prodPlac>
                France Recherche en Santé Humaine (FReSH)            </prodPlac>
      <fundAg>
                                            University Hospitals, Leicester                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="University Hospitals, Leicester" email="None@domain.com">
                    Manuel ;GALIÑANES
                                            <ExtLink title="RNSR" URI="" role="labo id"/>
                                    </contact>
      <contact affiliation="University Hospitals, Leicester" email="">
        <ExtLink title="RNSR" URI="" role="labo id"/>
      </contact>
      <depDate date="2026-07-03"/>
      <distDate date="2026-07-03"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <studyAuthorization>
    <authorizingAgency>Other                </authorizingAgency>
  </studyAuthorization>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    Myocardial Infarct</keyword>
      <keyword vocab="" vocabURI="">
                    Bone Marrow Cells</keyword>
      <topcClas vocab="health theme">
                        Cardiology and vascular medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/4455c187-2f2f-4cd1-a4dd-449f59d73b39 | http://data.europa.eu/8mn/euroscivoc/c42fc6ec-b216-4a24-9e9d-f5e781c175a0"/>
                                                            <ExtLink title="MeSH" URI="D002309"/>
                                                </topcClas>
    </subject>
    <abstract contentType="purpose">null</abstract>
    <abstract contentType="abstract">The purpose of this study is to determine whether the administration of patient's own bone marrow cells into scar areas of the heart, can improve the contractile function of these areas.</abstract>
    <sumDscr>
      <collDate event="start" date="2002-11-01"/>
      <collDate event="end" date="2007-07-01"/>
      <nation abbr="gb">
                    United kingdom
                                            <concept vocab="ISO" vocabURI="gb"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individus            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="D005260"/>
                                                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Other                                                            <concept vocab="MeSH"/>
                                                    </universe>
      <universe level="age" clusion="I">Young Adult (19 to 24 years)                                                            <concept vocab="MeSH" vocabURI="D055815"/>
                                                    </universe>
      <universe level="age" clusion="I">Adult (25 to 44 years)                                                            <concept vocab="MeSH" vocabURI="D000328"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="D008875"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="D000368"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged, 80 and over (80 years and more)                                                            <concept vocab="MeSH" vocabURI="D000369"/>
                                                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Biological data</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Contractile function of treated scar areas [Time Frame: 6 months]</description>
    </developmentActivity>
    <developmentActivity type="secondary evaluation">
      <description>Global left ventricular functions [Time Frame: 6 months]</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <frequenc>Incremental</frequenc>
      <sampProc>Complete enumeration (including consecutive recruitment)                                                            <concept vocab="CESSDA" vocabURI="TotalUniverseCompleteEnumeration"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through independent healthcare practitioners</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>&lt; 500 individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Measurements and tests                                                            <concept vocab="CESSDA" vocabURI="MeasurementsAndTests"/>
                                                    </collMode>
      <collMode>Physical/biological measurements (blood pressure, weight, biochemistry, imaging, etc.)                                                            <concept vocab="CESSDA" vocabURI="MeasurementsAndTests.Physical"/>
                                                    </collMode>
      <sources>
        <sources>
          <sourceCitation>
                                    
                                    
                                                                    </sourceCitation>
        </sources>
      </sources>
    </dataColl>
    <notes>Interventional Study</notes>
    <notes subject="research type">
                        Interventional Study                    </notes>
    <anlyInfo>
      <respRate>63</respRate>
    </anlyInfo>
    <stdyClas>Completed study</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Metadata-only access                                                            <ExtLink title="COAR" URI="http://purl.org/coar/access_right/c_14cb"/>
                                                    </avlStatus>
    </setAvail>
    <useStmt>
      <contact email="none@domain.com">Manuel;GALIÑANES</contact>
    </useStmt>
  </dataAccs>
</stdyDscr>
<dataDscr>
</dataDscr></codeBook>
