Genetic Polymorphism in Subjects with Type 2 Diabetes and Diabetic Nephropathy: Study “DIAB’2-NEPHRO-GENE” (DIABète de type 2, NEPHROpathie et GENEtique)

{
"level_sex_clusion_I": [
{
"value": "Male",
"concept": {
"vocab": "MeSH",
"vocabURI": "http:\/\/id.nlm.nih.gov\/mesh\/D008297"
}
},
{
"value": "Female",
"concept": {
"vocab": "MeSH",
"vocabURI": "http:\/\/id.nlm.nih.gov\/mesh\/D005260"
}
}
],
"level_age_clusion_I": [
{
"value": "Young Adult (19 to 24 years)",
"concept": {
"vocab": "MeSH",
"vocabURI": "http:\/\/id.nlm.nih.gov\/mesh\/D055815"
}
},
{
"value": "Adult (25 to 44 years)",
"concept": {
"vocab": "MeSH",
"vocabURI": "http:\/\/id.nlm.nih.gov\/mesh\/D000328"
}
},
{
"value": "Middle Aged (45 to 64 years)",
"concept": {
"vocab": "MeSH",
"vocabURI": "http:\/\/id.nlm.nih.gov\/mesh\/D008875"
}
}
],
"level_type_clusion_I": [
"Patients population"
],
"level_type_clusion_other": "",
"clusion_I": "Individuals included in the study are adult subjects who have given their signed informed consent and covered by a social security scheme or registered with a likewise scheme. We wish to include different subjects with type 2 diabetes in the DIAB2-NEPHRO-GENE study that can be divided into three groups: 1 - Case-control subjects (with no diabetic nephropathy) - subjects with diabetic retinopathy, regardless of stage - known type 2 diabetes for more than 5 years - normal urinary albumin excretion (UAE) (defined as urinary albumin concentration strictly below 20 mg\/l or 30 mg\/24h), twice occurring out of 3 consecutive samples over the last 5 years. - Normal UAE in the absence of conversion enzyme inhibitor or angiotensin II antagonist receptors - creatinine strictly less than 150M.2 - Case subjects (with diabetic nephropathy): - subjects with diabetic glomerulopathy confirmed by renal biopsy, even with absence of retinopathy - or subjects with the following characteristics: - diabetic retinopathy regardless of stage. - known type 2 diabetes for more than 5 years - abnormal urinary albumin excretion (UAE)(defined as urinary albumin concentration higher or equal to 20 mg\/l or 30 mg\/24h), twice occurring out of 3 consecutive samples over the last 5 years - with or without change to renal function (defined by creatinine higher than 150 µmol\/l, or need for extra-renal purification or renal transplantation). - absence of kidney disease other than diabetic nephropathy 3 - known type 2 diabetes for at least 5 years (recent diabetes) regardless of urinary albumin excretion or creatinine",
"clusion_E": ""
}